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KMID : 0043320150380091642
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Archives of Pharmacal Research
2015 Volume.38 No. 9 p.1642 ~ p.1650
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Application of chemical biology in target identification and drug discovery
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Zhu Yue
Xiao Ting
Lei Saifei
Zhou Fulai
Wang Ming Wei
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Abstract
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Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery.
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KEYWORD
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Chemical biology, Genomics, Proteomics, Drug discovery, Target validation, High-throughput screening (HTS)
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